Constructing Chimeric Antigen for Precise Screening of HTLV-I Infection.

Role of HLA-G 14 bp Indel polymorphism on susceptibility to HTLV-1 infection in blood donors of Khorasan Razavi Blood Center

Abstract Background and Objectives The HLA-G antigen is a non-classical HLA class-I with limited polymorphism. Several studies have indicated the role of a 14 bp Indel polymorphism rs371194629 in the 3'-UTR region of the HLA-G in acquisition of HTLV-1 infection. In this study, we investigated the correlation between the genotypes of this polymorphism and HTLV-1 infection in blood donors of Khor...

A Systematic Review for Estimation of HTLV-I Infection in the Blood Donors of Iran

Priming Hepatitis B Surface (HBsAg)- and Core Antigen (HBcAg)-Specific Immune Responses by Chimeric, HBcAg with a HBsAg ‘a’ Determinant

We developed an immunogen to stimulate multivalent immunity against hepatitis B surface antigen (HBsAg) and hepatitis B core antigens (HBcAg). Immune responses specific for both HBsAg and HBcAg play an important role in controlling the infection. HBsAg-specific antibodies mediate elimination of virions at an early stage of infection and prevent the spread of virus. The immunogen was constructed...

Assessment of HTLV-I proviral load, HIV viral load and CD4 T cell count in infected subjects; with an emphasis on viral replication in co-infection

  Objective(s): HTLV-I and HIV virus quantification is an important marker for assessment of virus activities. Since there is a direct relationship between the number of virus and disease progression, HTLV- I and HIV co-infection might have an influence on the development of viral associated diseases, thus, viral replication of these viruses and co-infection were evaluated.   Materials and...

Human T Lymphotropic Virus Type I (HTLV-I) Oncogenesis: Molecular Aspects of Virus and Host Interactions in Pathogenesis of Adult T cell Leukemia/Lymphoma (ATL)

    The study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. The processes ranging from viral infection to progressing malignancy are slow and usually insufficient for establishment of transformed cells that develop cancer in only ...